Best Fisetin Supplements

Written and reviewed by Dr Adam Williams, medical doctor and health writer. Last updated 3 July 2026.

Fisetin has become one of the most searched compounds in longevity, on the back of a single remarkable finding: in a 2018 study from Mayo Clinic and Scripps researchers, it was the most potent senolytic — a compound that clears "senescent" cells — of ten flavonoids screened, and it extended both healthspan and lifespan in aged mice.¹ That result launched a wave of interest, a shelf full of supplements, and a growing programme of human clinical trials.

It also launched a lot of hype. The purpose of this guide is to be the opposite. We've rated six credible fisetin supplements with a transparent HealthScore™, and then written what is intended to be the most thorough plain-English fisetin resource you'll find: the biology of senescent cells, the landmark study and exactly what it did (and didn't) show, the human clinical trials now under way, how fisetin works at the molecular level, the two very different dosing philosophies with the real research numbers, why fisetin is so hard to absorb and what to do about it, how it compares to quercetin and other senolytics, who should and shouldn't take it, and the safety picture. Read the whole thing and you'll understand fisetin better than most of the marketing that's selling it to you.

Contents

• The HealthScore™ scorecard
• How we score fisetin supplements
• The 6 best fisetin supplements, scored
• What is fisetin? Sources & chemistry
• Senescent cells, SASP & "inflammaging"
• The landmark senolytic study, in detail
• Fisetin human clinical trials (2026 status)
• How fisetin works: mechanisms of action
• Fisetin across the body's systems
• Fisetin benefits by area
• What the evidence does & doesn't show
• Dosage: daily vs the senolytic pulse (with real numbers)
• Bioavailability, metabolism & how to absorb it
• Fisetin vs quercetin & other senolytics
• Who should (and shouldn't) take it
• How to choose a fisetin supplement
• Safety, side effects & interactions
• Stacking fisetin
• Common mistakes & myths vs facts
• How to take it: practical protocol
• Glossary
• FAQs
• References & clinical trials

The HealthScore™ Scorecard

Bioavail. = bioavailability & form. Specifications and prices change; confirm current details, including exact fisetin content, on each product page before buying.

How We Score Fisetin Supplements

The HealthScore™ is built from the five factors that most determine whether a fisetin supplement is worth taking:

• Potency & dose (25): the amount of actual fisetin per serving, judged against how fisetin is used. It carries the most weight because dose is the biggest differentiator in this category — many products are underdosed.
• Purity & standardisation (20): the percentage of active fisetin in the extract. "500 mg" of a low-purity extract is not 500 mg of fisetin.
• Bioavailability & form (20): how well the format supports absorption — which matters more for fisetin than almost any other supplement, because it's so poorly absorbed.
• Testing & transparency (20): third-party testing for identity, potency and contaminants, plus honest labelling with no proprietary blends.
• Value (15): cost per milligram of fisetin, and UK accessibility.

This makes scores comparable and, importantly, explains why one product beats another: a liposomal blend can score well on bioavailability but lose points on potency; a high-dose capsule does the reverse. The winner is the product that balances all five best.

The 6 Best Fisetin Supplements, Scored

1. Welzo Ultra Purity Fisetin 500 — HealthScore™ 89/100

HealthScore™ breakdown: Potency 24 · Purity 18 · Bioavailability 14 · Testing 19 · Value 14.

The Welzo Ultra Purity Fisetin 500 takes the top HealthScore by dominating the two most heavily weighted criteria. Its 500 mg dose is the highest single-ingredient strength here, earning near-full potency marks where most rivals — at 100 mg — score in the mid-teens. That higher unit strength is genuinely useful: it covers a meaningful daily dose in one capsule, and because fisetin's fractional absorption is low, a higher dose partly compensates. It's also a convenient building block for the periodic higher-dose protocols people use for senolytic purposes (which should be done under medical guidance — see dosing).

On the other criteria it's consistently strong. It's part of the Welzo Ultra Purity™ range, third-party tested for identity, potency and contaminants (scoring 19/20 on testing & transparency), transparently labelled with no proprietary blend or filler, and GMP-manufactured. It dispatches from the UK with fast delivery and a returns policy, so UK buyers avoid the import charges and customs delays common with US longevity brands (14/15 on value). Its only relative weakness is bioavailability: it's a standard capsule rather than a liposomal or absorption-enhanced format — easily mitigated by taking it with a fatty meal.

Pros: highest dose in test; high purity; excellent testing/transparency; UK dispatch & returns; strong value.
Considerations: standard capsule (take with fat to aid absorption); start lower if new to fisetin.

Best for: the majority of buyers who want a high-quality, high-dose, UK-dispatched fisetin at sensible value. View Welzo Ultra Purity Fisetin 500 →

2. ProHealth Fisetin Pro — HealthScore™ 84/100

HealthScore™ breakdown: Potency 20 · Purity 17 · Bioavailability 18 · Testing 18 · Value 11.

ProHealth's Fisetin Pro posts the highest bioavailability score in the test, because it's formulated with absorption in mind — the smartest thing a fisetin brand can prioritise, given the compound's poor natural uptake. It comes from an established longevity brand with a strong biohacking following, publishes certificates of analysis, and is positioned squarely within a healthspan/senolytic context, so you know what you're buying and why. It loses ground only on value, being premium-priced and shipped internationally rather than from UK stock.

Best for: absorption-focused buyers who want a formulated product from a serious longevity brand. Confirm the current dose and formulation on the product page.

3. Double Wood Fisetin — HealthScore™ 81/100

HealthScore™ breakdown: Potency 16 · Purity 19 · Bioavailability 13 · Testing 18 · Value 15.

Double Wood earns the highest purity and value scores here: a high-purity extract (typically standardised to around 98%), cGMP-made and third-party tested for identity, potency and contaminants including heavy metals, at the lowest per-bottle price in the group. It's the transparency-and-value champion; it simply scores lower on potency at a standard per-serving dose, so a higher intake means more capsules and the value gap narrows.

Best for: budget-conscious buyers who want a high-purity, well-tested fisetin and are happy with a standard daily dose.

4. Codeage Liposomal Fisetin + Resveratrol + Luteolin — HealthScore™ 76/100

HealthScore™ breakdown: Potency 15 · Purity 16 · Bioavailability 18 · Testing 16 · Value 11.

Codeage ties for the top bioavailability score thanks to its liposomal delivery, and it adds two further longevity-associated polyphenols — resveratrol and luteolin — that are also studied in the senescence space. It's the convenient "one product covers several polyphenols" option, and the liposomal format directly targets fisetin's absorption problem. The trade-off, reflected in a lower potency score, is that the individual fisetin dose is smaller than a dedicated capsule.

Best for: those who want a liposomal, multi-polyphenol longevity formula rather than pure, high-dose fisetin.

5. Nutricost Fisetin — HealthScore™ 73/100

HealthScore™ breakdown: Potency 16 · Purity 15 · Bioavailability 12 · Testing 16 · Value 14.

Nutricost scores well on value — 100 mg per serving, non-GMO, gluten-free, GMP-made and third-party tested at a low price. It's a no-frills capsule with no absorption technology, which pulls down its bioavailability score, so take it with fat and expect to use a couple of capsules for a higher daily intake.

Best for: budget-focused buyers building their own stack who want the cheapest reliable fisetin.

6. Neurogan Fisetin — HealthScore™ 70/100

HealthScore™ breakdown: Potency 15 · Purity 15 · Bioavailability 13 · Testing 15 · Value 12.

Neurogan offers a clean, well-presented everyday fisetin capsule from a transparent brand. It scores solidly and evenly rather than excelling on any single axis; the main thing to verify is the per-serving dose, which sets its value against the higher-strength picks.

Best for: those who want a clean, simple everyday fisetin from a presentable brand.

What Is Fisetin? Sources & Chemistry

Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a flavonol — a flavonoid in the same broad family as quercetin and luteolin — and the yellow pigment in a range of plants. It carries four hydroxyl groups on its flavone backbone, and it's this structure that gives it strong antioxidant activity and the ability to interact with multiple cellular pathways. The richest dietary source is the strawberry, followed by apples, persimmons, grapes, onions, kiwi and cucumbers.

An important reality check before comparing diet with supplements: you cannot reach research-level fisetin through food. Even strawberries contain only a small amount per gram, so matching a supplemental dose — let alone a research dose — would mean eating kilograms daily. That's why concentrated extracts exist, usually standardised from the smoke tree (Cotinus coggygria) or similar sources to a high percentage of active fisetin. Purity matters, because a low-percentage extract delivers proportionally less of what you're paying for — which is precisely why it's a scored criterion above.

Senescent Cells, SASP & "Inflammaging"

To understand why fisetin generates so much interest, you need to understand cellular senescence. When a cell is damaged or stressed beyond repair — by DNA damage, oxidative stress, or simply reaching its replicative limit — it can enter senescence: it permanently stops dividing (which is protective, because it prevents damaged cells replicating and potentially becoming cancerous) but it does not die. Instead it lingers, sometimes called a "zombie cell."

The problem is what these cells do. Senescent cells secrete a cocktail of inflammatory cytokines, growth factors and enzymes known as the senescence-associated secretory phenotype (SASP) — signals that inflame and damage neighbouring healthy tissue. In youth, the immune system clears senescent cells efficiently. With age, both their production rises and their clearance falls, so they accumulate — in skin, joints, blood vessels, fat, muscle, brain and elsewhere — and their SASP secretions drive the chronic, low-grade inflammation researchers call "inflammaging." Using genetic and pharmacological tools, senescent cells have been shown to play a causal role in many features of ageing in animal models, from frailty to metabolic and cardiovascular decline.

This reframes ageing as something potentially actionable. A senolytic is a compound that selectively clears senescent cells while sparing healthy ones — in effect, taking out the "zombie cells" so tissue can renew. It's a more ambitious idea than simply supplying antioxidants: instead of buffering damage, it aims to remove a root-cause driver of ageing. Fisetin is one of the leading natural candidates for that job.

The Landmark Senolytic Study, in Detail

The pivotal work is Yousefzadeh and colleagues' 2018 study in EBioMedicine.¹ The team set out to find flavonoids with stronger senolytic activity than the then-leading combination of dasatinib and quercetin. They screened a panel of ten flavonoid compounds against senescent cells, and fisetin emerged as the most potent at selectively killing senescent cells while sparing healthy ones.

Crucially, the effect held up beyond the dish. In aged mice, fisetin reduced senescence markers across multiple tissues, and in human tissue samples (adipose explants) it reduced the burden of senescent cells too — early evidence of translational relevance. And the headline finding: chronic administration late in life extended both median and maximum lifespan in mice, even when treatment began at an advanced age, with few side effects. Extending both healthspan and lifespan from a natural product, started late, is what made the study land so hard and kick-started the current wave of research and products.

It's worth stating plainly what this study is and isn't. It is rigorous animal and human-tissue work demonstrating a mechanism and a lifespan effect in mice. It is not a demonstration that fisetin extends human lifespan or treats human disease. That gap — from compelling mouse data to proven human benefit — is exactly what the clinical trials below are designed to close.

Fisetin Human Clinical Trials (2026 Status)

One reason to take fisetin more seriously than the average "longevity" supplement is that it has moved into genuine human clinical trials, several run by leading academic centres. Here's an honest snapshot of the landscape — noting that most are ongoing, and that being in a trial is not the same as having proven a benefit.

Fisetin was chosen for several of these trials precisely because it has a history of safe human use, can be given orally, and has a short elimination half-life — properties that suit intermittent "hit-and-run" senolytic dosing. The honest read on all of this: fisetin is a serious research candidate with an active clinical programme, but published human efficacy results remain limited. Buy and use it as a promising supplement, not as a proven therapy — and don't infer that a trial in, say, Alzheimer's or cancer means fisetin "treats" those conditions. It doesn't; those studies are asking the question, not answering it.

How Fisetin Works: Mechanisms of Action

Fisetin is a genuinely multi-target molecule. In laboratory research it acts through several complementary pathways:

• Senolytic clearance: it tips senescent cells toward programmed cell death (apoptosis), partly by interfering with the pro-survival networks these cells rely on to resist dying — reducing their number and the inflammatory SASP signals they emit.
• Direct antioxidant + Nrf2 activation: fisetin both scavenges free radicals directly and switches on Nrf2, the master regulator of the cell's own antioxidant defences, boosting endogenous protectors such as glutathione. This "help the cell protect itself" mechanism is often more meaningful than direct scavenging alone.
• Anti-inflammatory (NF-κB): it dampens NF-κB signalling, a central switch for inflammatory gene expression — directly relevant to the inflammaging picture.
• Sirtuin support: fisetin has been studied as a modulator of sirtuins, the longevity-associated enzymes involved in DNA repair and metabolic regulation.
• Neuroprotection: it can cross the blood-brain barrier and, in models, supports pathways involved in memory (including modulation of inflammatory and p25/CDK5-related signalling) and protects neurons from oxidative and inflammatory stress.³

Clearing senescent cells and reinforcing the cell's own defences and calming inflammation is why fisetin is described as both a "senolytic" and a broader "senotherapeutic," and why it appears in so many longevity stacks.

Fisetin Across the Body's Systems

Because senescent cells accumulate everywhere, fisetin is being studied across multiple systems. Mapped to the trial landscape above, the areas of active interest are:

• Musculoskeletal & frailty: the flagship area — reducing senescent-cell burden and inflammation that contribute to frailty and loss of physical function (the focus of AFFIRM and the breast-cancer-survivor trial).
• Vascular health: senescent cells stiffen blood vessels and impair the endothelium; a dedicated trial is testing whether intermittent fisetin improves vascular function in older adults.
• Brain & cognition: neuroprotection in animal models and a planned trial in mild cognitive impairment / early Alzheimer's.
• Metabolic health: preclinical work suggests effects on blood-sugar handling and diabetic complications.
• Immune & inflammatory resilience: the rationale behind the COVID-19 senolytic pilot in vulnerable older adults.
• Peripheral nerve/tissue: a completed trial explored fisetin in carpal tunnel syndrome.

The consistent thread is senescence — the same underlying mechanism, tested in different tissues. Encouraging as a research programme; still unproven as human therapy.

Fisetin Benefits by Area

Framed honestly around what the research supports, this is what fisetin is most commonly taken for:

• Longevity & cellular senescence: its flagship area — clearing senescent cells and reducing inflammaging (strongest, though largely preclinical, evidence).
• Brain & cognitive health: studied for neuroprotection and cognitive maintenance in animal models; crosses the blood-brain barrier.
• Antioxidant & anti-inflammatory support: a potent antioxidant that also upregulates the body's own defences and calms inflammatory signalling.
• Metabolic support: researched in preclinical models for blood-sugar handling.
• Skin & tissue ageing: senescent cells accumulate in skin and connective tissue, making senolytics of interest here (early evidence).
• Vascular & physical function: under active human investigation (see trials).

These are areas of support and active study, not proven treatments. Fisetin is a wellness supplement, not a medicine.

What the Evidence Does & Doesn't Show

Dosage: Daily vs the Senolytic Pulse (With Real Numbers)

Fisetin is unusual because there are two genuinely different dosing philosophies, and confusing them is the most common mistake people make.

The pulse logic matters: because a senolytic aims to remove senescent cells rather than maintain an effect, it doesn't need to be present daily — you clear cells in a short burst, stop, and repeat occasionally. Fisetin's short half-life suits this. But note the two very different dose levels above: research "pulse" doses (20 mg/kg) are far higher than everyday supplementation, and their long-term safety in humans isn't yet established.

Clear guidance: for most people, daily support at a sensible dose is the reasonable default. If you're drawn to a high-dose pulse protocol, treat it as something to discuss with a clinician — ideally in the context of monitoring — rather than to copy from a forum. The Welzo Ultra Purity Fisetin 500's 500 mg strength suits daily higher-end use and gives a convenient unit for supervised protocols. Whatever the approach, take fisetin with food containing some fat.

Bioavailability, Metabolism & How to Absorb It

Fisetin's single biggest practical weakness — and a scored criterion above — is poor oral bioavailability. Three things work against it: it's poorly water-soluble, it's rapidly metabolised (conjugated by glucuronidation and sulfation in the gut and liver), and it has a short half-life, so blood levels rise and fall quickly. The practical consequence is that two products with the same label dose can deliver very different amounts of usable fisetin depending on formulation — which is exactly why bioavailability is worth 20 points in the HealthScore.

Ways to improve absorption, in rough order of ease:

• Take it with a fatty meal. Fisetin is fat-soluble, so dietary fat (olive oil, avocado, nuts, full-fat yoghurt) meaningfully aids uptake — the simplest, free intervention.
• Choose a formulated product — liposomal (as in Codeage's blend) or an absorption-enhanced formula (as ProHealth positions Fisetin Pro), designed to protect fisetin through digestion and improve delivery.
• Consider piperine (black pepper extract), which can slow the metabolism of some polyphenols and is often paired with them for this reason.
• Offset with dose — a higher-strength standard capsule delivers more total fisetin, partly compensating for lower fractional absorption. This is one reason a 500 mg capsule is a practical choice.

This is also why the exact human dose and formulation are active research questions: the pharmacokinetic sub-study within the current pilot trials is measuring how much fisetin (and which metabolites) actually reach the bloodstream after oral dosing.

Fisetin vs Quercetin & Other Senolytics

Fisetin sits within a small family of senolytic compounds that longevity-minded people compare and combine:

The practical takeaway: fisetin is the natural senolytic with the strongest single-compound animal data, quercetin has the human-protocol heritage via D+Q, and they're often viewed as complementary. If you stack, introduce one at a time, and get medical advice before any high-dose senolytic approach.

Who Should (and Shouldn't) Take It

Fisetin tends to appeal to people focused on healthy ageing and longevity, those building an antioxidant/anti-inflammatory routine, and those interested in brain and cognitive or vascular support. As a well-tolerated flavonoid with a history of safe human use, it's a reasonable option for many healthy adults.

It's not appropriate for everyone. Do not start fisetin without medical advice if you are pregnant or breastfeeding, if you take blood thinners or other regular medication, if you have a history of cancer (senolytics act on cell-survival and death pathways), or if you are under 18. And no supplement replaces the fundamentals — exercise, sleep and diet remain the most powerful levers on healthy ageing.

How to Choose a Fisetin Supplement

Safety, Side Effects & Interactions

Fisetin has been well tolerated in studies at typical doses, with mild digestive upset the most commonly reported effect, and it has a history of safe human use — which is partly why it was selected for clinical trials. Because it's a longevity compound sometimes taken at high doses, take these cautions seriously:

• Medication interactions: fisetin can affect cytochrome P450 enzymes and may interact with blood thinners/antiplatelet drugs and other medicines — check with your GP or pharmacist before starting.
• High "senolytic" doses (e.g. 20 mg/kg pulses) are not fully characterised for long-term human safety. Don't self-experiment with aggressive online protocols; keep high-dose use medically supervised.
• Cancer history: because senolytics act on cell-survival and cell-death pathways, anyone with a history of, or active, cancer should consult their oncologist or GP first — even though fisetin is being studied in cancer survivors, that's within a monitored trial, not self-directed use.
• Pregnancy & breastfeeding: safety isn't established — avoid without medical advice.
• Under-18s: not intended for use.
• General: introduce one supplement at a time, use the lowest effective dose, and read the label and patient information.

Food supplements support — not replace — a balanced diet, a healthy lifestyle and professional medical advice.

Stacking Fisetin

Fisetin pairs logically with compounds on complementary pathways — the aim being different mechanisms, not duplication:

Introduce one compound at a time so you can judge tolerability. Training, sleep and diet remain the foundation any stack is built on.

Common Mistakes & Myths vs Facts

• Myth: "Fisetin is proven to extend human lifespan." Fact: lifespan extension is shown in mice; human trials are ongoing and haven't proven this.
• Mistake: copying high-dose "senolytic pulse" protocols from the internet. Research pulses (20 mg/kg) are trial doses; do them only with medical oversight.
• Mistake: ignoring absorption. Taking fisetin on an empty stomach as a plain powder wastes much of the dose — take it with fat or choose a formulated product.
• Myth: "You can get enough from strawberries." Fact: dietary amounts are a tiny fraction of supplemental (let alone research) doses.
• Mistake: judging products by headline milligrams alone. Purity and format determine how much active, absorbed fisetin you actually get — which is why the HealthScore weighs both.
• Myth: "More is always better." Fact: senolytics follow a periodic-clearance logic, not a more-is-better one, and high chronic dosing isn't well studied.

How to Take It: Practical Protocol

• Timing: take fisetin with your largest, fattiest meal of the day for best absorption.
• Start low: if you're new to it, begin at the lower end and build up, watching for any digestive upset.
• Be consistent (daily use): antioxidant/anti-inflammatory benefits build over weeks — give it 4–8 weeks.
• Don't improvise pulses: if you're interested in a senolytic protocol, discuss it with a clinician rather than copying an internet regimen.
• Track and review: note how you feel, and reassess periodically rather than taking it on autopilot.
• Store cool and dry, away from light, and keep out of reach of children.

Glossary

• Senescence: a state in which a damaged cell stops dividing but doesn't die.
• Senolytic: a compound that selectively clears senescent cells.
• Senotherapeutic: a broader term for compounds that target senescence, whether by clearing cells (senolytic) or calming their secretions (senomorphic).
• SASP: senescence-associated secretory phenotype — the inflammatory signals senescent cells release.
• Inflammaging: chronic, low-grade inflammation that rises with age, partly driven by senescent cells.
• Nrf2: a master regulator that switches on the cell's own antioxidant defences.
• Autophagy: the cell's "self-cleaning" recycling process (the pathway spermidine supports).
• Flavonol: the subclass of flavonoid that fisetin (and quercetin) belong to.

Frequently Asked Questions

What is the best fisetin supplement?

By HealthScore™, the Welzo Ultra Purity Fisetin 500 (89/100) — high 500 mg dose, third-party tested, UK-dispatched. ProHealth Fisetin Pro (84) leads on absorption; Double Wood Fisetin (81) on value and purity.

What does fisetin do?

An antioxidant/anti-inflammatory flavonoid best known as a senolytic — in research it cleared senescent cells and extended lifespan in mice. Human benefits are still being tested in clinical trials.

What's the best fisetin dosage?

Daily: ~100–500 mg. The human senolytic research dose is ~20 mg/kg for two consecutive days, repeated periodically — experimental, and for medical supervision only. Take with a fatty meal.

Are there human trials on fisetin?

Yes — including Mayo's AFFIRM (frailty), a COVID-19 pilot, vascular-function and breast-cancer-survivor trials, and pharmacokinetic/safety studies. Most are ongoing, so efficacy isn't established.

Is fisetin poorly absorbed?

Yes — poorly water-soluble, rapidly metabolised and short half-life. Liposomal/formulated versions, taking with fat, adding piperine, or a higher dose all help.

Fisetin or quercetin?

Both are senolytic flavonoids; fisetin was most potent in the 2018 screen, quercetin has the D+Q human heritage. Some combine them — one at a time, with advice before high doses.

How long does fisetin take to work?

Daily antioxidant/anti-inflammatory support builds over weeks; senolytic clearance follows a short "pulse" rather than a felt daily effect, and human timelines aren't established. Give daily use 4–8 weeks.

Can I get enough fisetin from strawberries?

No — strawberries are the richest source but contain far too little to reach research-level doses, which is why concentrated supplements are used.

Is fisetin safe?

Well tolerated at typical doses with a history of safe human use; mild digestive upset is most common. Possible interactions with blood thinners; high-dose long-term safety is unclear; consult a doctor if pregnant, on medication, or with a cancer history.

References & Clinical Trials

Key studies

1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18–28. DOI
2. Zhang J, et al. Fisetin and quercetin: modulators of cellular senescence. Exp Gerontol. 2023;174:112133. PubMed
3. Currais A, et al. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. 2014.
4. Verdoorn BP, et al. Fisetin for COVID-19 in skilled nursing facilities: senolytic trials in the COVID era. J Am Geriatr Soc. 2021. PMC
5. Li H, et al. Senolytic fisetin reduces inflammaging and extends healthspan (review). Nutrients. 2023;15(4):948.

Selected human clinical trials (ClinicalTrials.gov)

1. AFFIRM — fisetin, frailty & inflammation in older women. NCT03430037
2. COVID-FIS — fisetin senolytic pilot in COVID-19. NCT04537299
3. Fisetin & vascular function in older adults. NCT06133634
4. Fisetin & physical function in breast cancer survivors. NCT05595499
5. Fisetin pharmacokinetics & safety (20 mg/kg/day × 2 days). NCT06431932
6. FITCATS — fisetin for carpal tunnel syndrome (completed). NCT05416515

About the author. Dr Adam Williams is a medical doctor and health writer who produces evidence-based supplement and healthy-ageing content. He assesses products on dose, purity, bioavailability, testing and value, and grounds his writing in peer-reviewed research and registered clinical trials. This content is for general education and is not personalised medical advice; always consult your own doctor about your circumstances.

Transparency note: HealthScored may have commercial relationships with some brands or retailers featured. HealthScore™ ratings are based on the transparent criteria described above and are not influenced by those relationships.

Medical disclaimer: This article is for general information and educational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Food supplements should not replace a varied, balanced diet and healthy lifestyle. Always read the product label and consult your GP, pharmacist or a qualified healthcare professional before starting any new supplement — particularly if you are pregnant, breastfeeding, taking medication (including blood thinners), or managing a health condition, including any history of cancer. High-dose "senolytic" protocols are experimental and should only be undertaken under medical supervision. References to clinical trials indicate that fisetin is being studied for those conditions, not that it is a proven or approved treatment for them. Statements about fisetin reflect emerging nutritional research and are not intended to diagnose, treat, cure or prevent any disease. Prices, availability and specifications are correct at the time of writing and may change.