By Dr Sarah Adams, longevity health writer for AllHealthStore. Last updated 3 July 2026.
The short version: I bought and personally tested six of the most talked-about NAD supplements in the UK over eight weeks, rating each on how easy it was to take, how well I tolerated it, how I felt on it, and value for money. My overall favourite was the Welzo Ultra Purity Liposomal NAD+ 1000 — the easiest to stick with, gentle on my stomach, a high 1,000 mg direct NAD+ dose, and the best value with fast UK delivery. Everything below is my honest, first-hand experience, not clinical proof.
I've written about longevity supplements for years, but there's no substitute for actually living with a product. So instead of another spec sheet, I did the thing readers keep asking for: I bought all six with my own routine in mind, took each properly, and kept notes — on the capsule size, whether it upset my stomach, whether I noticed anything, and whether I'd genuinely re-buy it. NAD supplements aren't magic and they aren't stimulants, so this was never going to be dramatic. But the practical differences between products — tolerability, convenience, value — turned out to matter a lot. Here's what eight weeks taught me.
How I Tested (My Method & Its Limits)
- Duration: each product taken daily as directed, with a settling-in period, across an eight-week testing window.
- What I tracked: ease of use (capsule size, format, routine fit), tolerability (any digestive effects), subjective feel (energy, focus, sleep), and value.
- How I scored: a simple 1–5 rating per category from my own notes, averaged into an overall score.
- Honest limits: this is one person's experience (n=1). I did not measure blood NAD+ or run a controlled trial, and subjective effects can be influenced by placebo, sleep, stress and diet. Read the scores as lived experience, not evidence of efficacy.
Tried & Tested: My Results at a Glance
| # | Product | Form | Ease of use | Tolerability | How I felt* | Value | Overall* |
|---|---|---|---|---|---|---|---|
| 1 | Welzo Ultra Purity Liposomal NAD+ 1000 | NAD+ 1,000 mg | 5 | 5 | 4.5 | 5 | 4.9 |
| 2 | Tru Niagen | NR 300 mg | 5 | 5 | 4 | 3.5 | 4.4 |
| 3 | Nuchido TIME+ | NAD+ booster | 4 | 4.5 | 4.5 | 3.5 | 4.3 |
| 4 | ProHealth NMN Pro | NMN 500 mg | 4.5 | 4.5 | 4 | 4 | 4.1 |
| 5 | Elysium Basis | NR + pterostilbene | 5 | 4.5 | 3.5 | 3.5 | 3.9 |
| 6 | Renue By Science | Liposomal NMN/NAD+ | 4 | 4 | 3.5 | 3.5 | 3.7 |
*"How I felt" and "Overall" are my subjective impressions from personal use over eight weeks. They are not measures of clinical effectiveness, and your experience may differ. Specifications and prices change — confirm on each product page.
The 6 NAD Supplements, Tried & Tested
1. Welzo Ultra Purity Liposomal NAD+ 1000 — My Overall Winner
What it is: a direct NAD+ supplement delivering 1,000 mg in a liposomal format, third-party tested, dispatched from the UK.
How it was to take: the simplest of the six to live with — a straightforward once-daily routine that I never had to think about. It sat completely fine with my stomach from day one, with none of the mild queasiness I sometimes get starting a new supplement.
What I noticed: nothing dramatic in week one (as expected — this isn't caffeine), but by around weeks three to four I felt my afternoon dip was a little less pronounced and my energy across the day felt steadier. I'll be honest that this is subjective and could be influenced by other factors, but it was the product I most wanted to keep taking.
Value & practicality: the highest direct NAD+ dose in my test, at a price well below the premium longevity brands, with fast UK delivery and easy re-ordering. That combination is why it topped my list.
Verdict: my overall winner — the one I'd genuinely re-buy and the one I'd point most people to first. View Welzo Ultra Purity Liposomal NAD+ 1000 → It's part of the wider Welzo Ultra Purity range.
2. Tru Niagen — The Reassuringly Well-Researched One
What it is: the best-researched NR (nicotinamide riboside) product, using patented Niagen at 300 mg.
How it was to take: a single small capsule — the most frictionless of the lot — and flawless tolerability throughout.
What I noticed: honestly, no obvious day-to-day feeling, which is what I'd expect from a modest NR dose. What I liked was the peace of mind: this is the ingredient with the deepest clinical record, and taking it felt reassuring even without a noticeable effect.
Verdict: the pick if evidence and simplicity matter more than dose or a "feel". The main downside is the premium price for 300 mg.
3. Nuchido TIME+ — The Premium UK "Whole-System" One
What it is: a UK-made, multi-ingredient NAD+ "booster" combining a precursor with vitamins, zinc, alpha-lipoic acid and botanicals.
How it was to take: three capsules a day with breakfast — more of a commitment than a single capsule, and worth noting it contains a little caffeine, so I kept it to mornings.
What I noticed: of the six, this was one where I felt a gentle, general sense of wellbeing and steadier energy build over the weeks. Subtle, not night-and-day, but pleasant.
Verdict: a polished, science-forward UK option if you like a formulated, whole-system approach and don't mind three capsules and a premium price.
4. ProHealth NMN Pro — The NMN I'd Recommend to NMN Fans
What it is: a 500 mg NMN precursor with a sublingual option and publicly available certificates of analysis.
How it was to take: I tried the sublingual route — slightly chalky held under the tongue, but fine, and easy to build into a morning routine. No digestive issues.
What I noticed: comparable to the other precursors — no strong subjective "feel", but a clinically-relevant NMN dose I felt confident about thanks to the transparent testing.
Verdict: my pick if you specifically prefer NMN and want a proper dose with transparent lab documentation. Ships internationally rather than from UK stock.
5. Elysium Basis — Polished, Premium, No Drama
What it is: a recognisable NR-plus-pterostilbene formula developed with academic advisors and NSF Certified for Sport.
How it was to take: easy capsules, no tolerability issues, nicely packaged — it feels premium in the hand.
What I noticed: no distinct subjective effect for me, similar to the other lower-dose NR options. It's a credible, well-certified product; I just didn't feel a difference.
Verdict: a solid, reassuringly certified NR combination if you like the brand — but one of the pricier options per month.
6. Renue By Science — The Format Experimenter's Choice
What it is: a biohacker-favourite range of liposomal and sublingual NAD+, NMN and NR formats.
How it was to take: the format variety is fun to experiment with, though it took a little more attention to get the routine right, and I had to read the labels carefully to check I was getting a sensible dose.
What I noticed: no clear subjective effect for me. My main practical note is to check the per-serving dose, as some liposomal formats are lower than they first appear.
Verdict: a flexible option for format tinkerers who read the dose carefully; ships from overseas.
What Is NAD+ (and Why I Bothered Testing These)?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell that's essential for turning food into energy and for DNA repair. Its levels fall with age, which is why NAD supplements — either direct NAD+ or the precursors NMN and NR — have become such a big part of the longevity conversation. Studies show precursors reliably raise blood NAD+ levels; direct NAD+ uses liposomal delivery to help absorption. What the science doesn't yet prove is a dramatic, guaranteed felt benefit in healthy people — which is exactly why I wanted to test them in the real world rather than take the marketing at face value.
An Honest Word on What Testing Can and Can't Tell You
I want to be straight about this: my ratings reflect how these products were to live with and my personal, subjective impressions — not clinical effectiveness. A "feel" over eight weeks can come from genuine physiology, from placebo, or simply from paying more attention to my sleep and habits during a test. That's not a reason to dismiss real-world experience — convenience and tolerability genuinely affect whether you'll stick with something — but it is a reason not to treat one person's notes as proof. If you want the evidence side, look for products with clinical dosing and third-party testing, and give any of them a fair 4–8 week run.
How to Choose (What I'd Tell a Friend)
- Want the simplest high-dose option with UK delivery? The Welzo Ultra Purity Liposomal NAD+ 1000 — my overall winner.
- Want the deepest research record? Tru Niagen (NR).
- Prefer NMN specifically? ProHealth NMN Pro.
- Like a formulated, whole-system UK product? Nuchido TIME+.
- Whatever you choose: pick a clear, adequate dose, third-party testing, and — for UK buyers — UK dispatch to avoid import charges.
What I Stack With NAD+
NAD+ works well alongside compounds on complementary pathways. These verified Welzo Ultra Purity options are what I'd reach for:
| Compound | Why I pair it | Option |
|---|---|---|
| NMN | A precursor to pair with direct NAD+ | Welzo Ultra Purity NMN |
| TMG (betaine) | Methyl-donor support during NAD+ metabolism | Welzo Ultra Purity TMG |
| Spermidine | Autophagy-linked cellular renewal | Welzo Ultra Purity Spermidine |
| Astaxanthin | Antioxidant support | Welzo Ultra Purity Astaxanthin |
| Berberine | Metabolic-health support | Welzo Ultra Purity Berberine |
Add one at a time, and browse the full NAD+ supplements collection or the Ultra Purity range to build your routine.
Safety & Precautions
In my testing, tolerability was good, with only occasional mild digestive upset when starting a new product. As with any supplement, take sensible precautions:
- If you are pregnant or breastfeeding, don't take an NAD supplement without advice from your GP or midwife.
- If you take medication, have a health condition, or any history of cancer, speak to your doctor first.
- Not intended for under-18s. Introduce one product at a time and read the label.
Supplements support — not replace — a balanced diet and healthy lifestyle, and are not a substitute for professional medical advice.
Tried & Tested FAQs
What is the best NAD supplement after testing?
My overall winner after eight weeks was the Welzo Ultra Purity Liposomal NAD+ 1000 — easiest to take, gentle on my stomach, high 1,000 mg dose, best value with UK delivery. This is my subjective experience, not clinical proof.
Can you feel NAD supplements working?
They're not stimulants, so there's no instant kick. Any changes I noticed were subtle and built over weeks — mostly steadier afternoon energy. Subjective effects can be placebo and vary between people.
How long did it take to notice anything?
Around 3–4 weeks for any subtle change. Allow at least 4–8 weeks before judging.
Did they cause side effects?
Tolerability was good overall, with occasional mild digestive upset when starting that settled within days.
Direct NAD+ or a precursor?
Precursors (NR, NMN) have the strongest evidence for raising NAD+; direct NAD+ uses liposomal delivery for absorption. In use, I preferred the high-dose liposomal NAD+ for convenience and value.
How much should I take?
Commonly up to 1,000 mg for direct NAD+, 300–1,000 mg for NR, and 250–500 mg for NMN. Follow the label.
Where can I buy NAD+ in the UK?
You can buy the Welzo Ultra Purity Liposomal NAD+ 1000 directly from Welzo with UK dispatch, which made re-ordering easy during testing.
About the author. Dr Sarah Adams is a longevity-focused health writer for AllHealthStore who tests supplements first-hand and reports her honest experience. Her reviews prioritise real-world usability, tolerability and value, alongside dose and third-party testing. This article reflects personal experience and general education, not personalised medical advice.
Transparency note: products were tested as part of editorial review. AllHealthStore may have commercial relationships with some brands or retailers featured; this does not change the honest, first-hand impressions described above.
Medical disclaimer: This article describes one person's personal testing experience and is for general information and educational purposes only. It is not clinical evidence and is not a substitute for professional medical advice, diagnosis or treatment. Individual experiences vary and may be influenced by placebo and lifestyle factors. Food supplements should not replace a varied, balanced diet and healthy lifestyle. Always read the product label and consult your GP, pharmacist or a qualified healthcare professional before starting any new supplement — particularly if you are pregnant, breastfeeding, taking medication, or managing a health condition, including any history of cancer. Statements about NAD+, NMN and NR reflect emerging nutritional research and are not intended to diagnose, treat, cure or prevent any disease. Prices, availability and specifications are correct at the time of writing and may change.